Cytochrome P450 1A1 and aromatase (CYP19) in cetaceans
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Cytochrome P450 1A1 and aromatase (CYP19) in cetaceans enzyme expression and relationship to contaminant exposure by Joanna Yvonne Wilson

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Published by Massachusetts Institute of Technology, Woods Hole Oceanographic Institution in Cambridge, Mass, Woods Hole, Mass .
Written in English


  • Cetacea -- Physiology.,
  • Marine mammals -- Effect of water pollution on.,
  • Cytochrome P-450.,
  • Aromatase.

Book details:

Edition Notes

Statementby Joanna Yvonne Wilson.
SeriesMIT/WHOI -- 2003-20., MIT/WHOI (Series) -- 2003-20.
The Physical Object
Pagination260 p. :
Number of Pages260
ID Numbers
Open LibraryOL16105352M

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Structure−Function Relationships of Inhibition of Human Cytochromes P 1A1, 1A2, 1B1, 2C9, and 3A4 by 33 Flavonoid Derivatives. Chemical Research in Toxicology , 23 (12), DOI: /txd. Vasilis P. Androutsopoulos, Naichang Li and Randolph R. J. by: Aromatase is a cytochrome P, hemoprotein-containing enzyme, located in the endoplasmic reticulum, which catalyzes the rate-limiting step in the conversion of androgens (androstenedione and testosterone), to estrogens (estrone and estradiol). Agents that inhibit aromatase (aromatase inhibitors) are widely used to prevent the development and progression of estrogen dependent breast cancers.   The cytochrome P (P) enzymes first attracted interest because of their relevance to the metabolism of drugs, steroids, and carcinogens. Collectively, the 57 human Ps are involved in Cited by: Erika L. Abel, John DiGiovanni, in The Molecular Basis of Cancer (Third Edition), Cytochrome P Polymorphisms. CYP1B1, CYP1A1, CYP1A2, CYP2E1, and CYP3A4 have all been shown to participate in the biotransformation of procarcinogens to ultimate carcinogens as noted in the preceding section (and reviewed in 77).Interestingly, these genes are generally well conserved and few .

Huang P, et al. Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on the expression of cytochrome P 1A1, the aryl hydrocarbon receptor, and the aryl hydrocarbon receptor nuclear translocator in rat brain and pituitary. Toxicol Appl Pharmacol. ; –Cited by: An alternative mechanism involves chemical changes in the heme group at the catalytic site. Similarly to other cytochrome P enzymes, the catalytic site of aromatase contains an Fe(III) heme group that, after reduction to Fe(II) affording species , binds to an oxygen molecule that becomes activated, giving A further one-electron reduction leads to peroxide anion , which can. In addition, many cytochrome P enzymes have been implicated in the metabolism of psychoactive drugs such as neuroleptics and antidepressants. The regulation of cytochrome P expression has been studied at greater detail, the regulation of aromatase being a Cited by: Aromatase, also called estrogen synthetase or estrogen synthase, is an enzyme responsible for a key step in the biosynthesis of is CYP19A1, a member of the cytochrome P superfamily (EC ), which are monooxygenases that catalyze many reactions involved in particular, aromatase is responsible for the aromatization of androgens into s: CYP19A1, ARO, ARO1, CPV1, CYAR, CYP19, .

Cytochrome P oxidoreductase (POR) deficiency is a recently characterized cause of congenital adrenal hyperplasia, which affects the enzymatic activity of all microsomal P enzymes, including the steroidogenic enzymes Pc17, Pc21, and Paro. POR is a flavoprotein that is required for the action of all microsomal p enzymes. Cytochrome P, family 1, subfamily A, polypeptide 1 is a protein that in humans is encoded by the CYP1A1 gene. The protein is a member of the cytochrome P superfamily of enzymes. Function Metabolism of xenobiotics and drugs. CYP1A1 is involved in phase I xenobiotic and drug metabolism Aliases: CYP1A1, AHH, AHRR, CP11, CYP1, P1 . UniProtKB - P (CP1A1_HUMAN)))) Display Cytochrome P 1A1. Gene. CYP1A1. Organism. Homo sapiens (Human) Status. Reviewed-Annotation score: Experimental evidence at protein level i. Function i. A cytochrome P monooxygenase involved in the metabolism of various.   Vorozole and letrozole are third-generation aromatase (cytochrome P 19A1) inhibitors. [11 C]-Vorozole can be used as a radiotracer for aromatase in living animals but when administered by IV, it collects in the atment with letrozole does not affect the binding of vorozole in the by: 2.